Driving Directions From Tampa To 4260 Saint Lawrence Dr, New Port Richey, Fl Start By Getting On Fl-60 W Or I-275 N, Depending On Your Location In Tampa. Merge Onto Fl-589 N / Veterans Expressway (Toll Road) Heading North. Continue On Fl-589 N For About 25 Miles. Take Exit 19 For Fl-54 Toward New Port Richey / Land O' Lakes. Turn Left (West) Onto Fl-54 W / State Road 54 W. Continue On Fl-54 W For About 9 Miles. Turn Right Onto Little Rd. Drive North On Little Rd For About 2 Miles. Turn Right Onto Saint Lawrence Dr. 4260 Saint Lawrence Dr Will Be On Your Right.